Local Delivery of CTGF siRNA with Poly(sorbitol-co-PEI) Reduces Scar Contraction in Cutaneous Wound Healing

Cutaneous wound healing: Significance of proteoglycans in scar formation

Proteoglycans (PGs), components of extracellular matrix (ECM), play an important role in modulating the structure and regulating the functions of the skin. The timely turnover of PGs influence the development and differentiation of cells. Wound healing also depends on the level of PGs which if not adequate leads to abnormal scars. The role of PGs in different phases of wound healing and their i...

Wound healing--scar wars.

Scafring following wounding is a major medical problem. In skin wounds or bums scarring often leads to adverse cosmesis and consequent psychological problems, adverse function particularly over joints and retardation of growth especially in children. Scarring in muscle adversely affects movement and can cause ankylosis. In abdominal and pelvic organs scarring can lead to life threatening strict...

Systemic Wound Healing Associated with local sub-Cutaneous Mechanical Stimulation

Degeneration is a hallmark of autoimmune diseases, whose incidence grows worldwide. Current therapies attempt to control the immune response to limit degeneration, commonly promoting immunodepression. Differently, mechanical stimulation is known to trigger healing (regeneration) and it has recently been proposed locally for its therapeutic potential on severely injured areas. As the early stage...

Cutaneous wound healing

Chemokines in cutaneous wound healing.

Healing of wounds is one of the most complex biological events after birth as a result of the interplay of different tissue structures and a large number of resident and infiltrating cell types. The latter are mainly constituted by leukocyte subsets (neutrophils, macrophages, mast cells, and lymphocytes), which sequentially infiltrate the wound site and serve as immunological effector cells but...